Abstract: This research project examines how organizations can develop innovative solutions to large-scale socio-economic problems in emerging markets through multi-stakeholder partnerships. The objective is to determine how these partnerships are built, what the optimal configuration of partners is, and how the partnerships should be coordinated. We primarily use network theory to anchor our study. The research setting consists of 33 health clinics for truck drivers along African transport corridors. These are all managed by the same non-profit foundation (North Star Alliance), but each depends on a different constellation of partners from the public, private and non-profit sectors. We expect that clinics’ ability to innovate in healthcare delivery and therefore treat more patients from different populations will depend on the composition of its portfolio of partners and the way that its managers coordinate with these partners as well as with other clinics in the intra-organizational network. Our dependent variables are the number and type of patients that are treated at a clinic in a given month, as well as some indicators of the type and quality of treatment.